Targacept Announces Initiation Of Phase 2 Studies Of TC-6987 In Type 2 Diabetes
Targacept, Inc. , a clinical-stage biopharmaceutical company announced the initiation of another Phase 2 clinical studies of its product candidate TC-6987 in disorders characterized by inflammation, one in asthma and one in Type 2 diabetes.
TC-6987
TC-6987 is a “modulator of the alpha7 neuronal nicotinic receptor and was discovered by Targacept scientists. A large body of scientific evidence highlights the key role that the alpha7 receptor plays in pathways mediated by pro-inflammatory molecules known as cytokines, and published studies suggest that alpha7 modulation modifies the inflammatory response by inhibiting cytokine production and release.”
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Phase 2 Study
The Phase 2 studies are planned to provide valuable insights to guide the selection of the therapeutic indications for which TC-6987 is best suited for later-stage development. "The alpha7 nicotinic receptor subtype occupies a critical position in regulating the severity of inflammation, and, as such, represents a promising target for development of much needed new treatments for debilitating inflammatory and autoimmune diseases," said Kevin J. Tracey, M.D., Director and Chief Executive of The Feinstein Institute for Medical Research.
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